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How does Tadapox Tablet affect the production of cyclic guanosine monophosphate (cGMP)?

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stephenbarkin

Member
Tadapox is a combination medication containing Tadalafil and Dapoxetine. While Dapoxetine is primarily used as a selective serotonin reuptake inhibitor (SSRI) to treat premature ejaculation, Tadalafil affects erectile function through its action on cyclic guanosine monophosphate (cGMP).


Here’s how Tadalafil in Tadapox affects cGMP production:


  1. Inhibition of PDE5: Tadapox Tablet is a phosphodiesterase type 5 (PDE5) inhibitor. PDE5 is an enzyme that breaks down cGMP, a molecule that plays a key role in regulating blood flow in the penis. By inhibiting PDE5, Tadalafil prevents the breakdown of cGMP, thereby increasing its levels in the body.
  2. Increased cGMP Levels: When sexual stimulation occurs, nitric oxide (NO) is released in the erectile tissue of the penis. NO activates the enzyme guanylate cyclase, which increases the production of cGMP. Higher cGMP levels cause the smooth muscles in the penile arteries to relax, leading to increased blood flow into the penis and resulting in an erection.
  3. Sustained Erection: By maintaining higher levels of cGMP, Tadalafil helps sustain an erection by ensuring that the blood vessels remain dilated and the blood flow continues to be directed towards the erectile tissues.


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